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商品详细ECM生物科学/膜联蛋白家族抗体试剂盒/试剂盒/AK6730
ECM生物科学/膜联蛋白家族抗体试剂盒/试剂盒/AK6730
ECM生物科学/膜联蛋白家族抗体试剂盒/试剂盒/AK6730
商品编号: AK6730
品牌: ecmbio
市场价: ¥8100.00
美元价: 4050.00
产地: 美国(厂家直采)
公司:
产品分类: 蛋白交联剂
公司分类: Crosslinkers
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
The Annexin family is composed of at least thirteen mammalian genes (Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. Annexins have roles in membrane fusion, endocytosis, secretion, and repair. Annexin A1 binds to cellular membranes in a calcium-dependent manner, promotes membrane fusion and endocytosis, and has been implicated as an anti-inflammatory mediator. Annexin A2 is a cytoskeletal calcium-dependent phospholipid binding protein, which has been shown to be a mediator of corticosteroid activity, a substrate for serine/threonine kinases and growth regulated tyrosine kinases, and may play a role in secretion. Annexin A5 is a PKC inhibitor, directly interacts with VEGFR2 receptor, and binds phosphatidylserine to inhibit blood coagulation. Annexin A6 reverses transformation of A431 cells after overexpression, and this effect may involve annexin A6 targeting of p120 RasGAP to the plasma membrane to inactivate Ras.
References
Zokas, L. & Glenney, J.R. (1987) J Cell Biol. 105:2111.Feinberg, J.M. et al. (1991) J Histochem. & Cytochem. 39:955.Grewal T & Enrich C (2009) Cell Signal. 21(6):847.Boye TL & Nylandsted J (2016) Biol Chem. 397(10):961.

Western blot of human PC3 cells (lane 1), human breast tissue (lane 2), lung tissue (lane 3), skin tissue (lane 4), and brain tissue (lane 5). The blot was probed with mouse monoclonal anti-Annexin A5 antibody (AM0171) at 1:500 (lanes 1-5).

Immunocytochemical labeling of Annexin A1 in paraformaldehyde fixed human A549 cells. The cells were labeled with mouse monoclonal anti-Annexin A1 (clone M021). The antibody was detected using goat anti-mouse Ig DyLight® 594.

Mouse monoclonal antibodies are supplied in phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide. Store all at –20°C. Stable for 1 year.

The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.

*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blotmobilities of known proteins with similar MW.

Product References:

AM2981 Moylan, J. et al. (2014) Redox biology 2:910. WB: C2C12 myoblastAM2981 Gilliam, L.A. et al. (2011) AJP Lung Cell Mol Phys 300:L225. IHC: mouse diaphragm

This kit contains:

CATALOG#DESCRIPTIONSIZEAPPLICATIONSSPECIES REACTIVITYMW (kDa)
AM0211
Annexin A1 Mouse mAb50 μlWB, E, IP, ICCHu38
AM0181
Annexin A1 Mouse mAb50 μlWB, E, IP, ICC, IHCHu, Rt, Ms, Bv38
AM0091
Annexin A2 Mouse mAb 50 μlWB, E, ICC, IP-MSHu36
AM2981
Annexin A2 (C-terminal region) Mouse mAb50 μlWB, E, IP, ICC, IHCHu, Rt, Ms, Ck36
AM0171
Annexin A5 Mouse mAb50 μlWB, E,IP-MSHu35
AM3301
Annexin A6 Mouse mAb50 μlWB, E, IPHu, Rt, Ms67
KIT SUMMARY

The annexin family antibody sampler kit can be used to detect the expression level of annexin A1, A2, A5, and A6. The kit includes high affinity mouse monoclonal antibodies to examine annexin A1, A2, A5, or A6 expression levels in western blot, ELISA, immunoprecipitation, and immunocytochemistry.

品牌介绍
ECM Biosciences是一家著名的生物公司,开发新的生物技术的生命科学研究。公司工程与研究机构全球发展创新的工具,以提高研究和治疗相关的神经病理学,癌症,免疫功能障碍和心血管疾病。产品列表:品牌名称1FM0141100微升ECM生物科学FXYD5 / Dysadherin(细胞外区域)小鼠单克隆IgG13AM2091100ulECM生物科学c-Abl(Tyr-245),磷酸化特异性兔多克隆5AP1271100ulECM生物科学Abp1(C端区域)小鼠单克隆IgG17AP1671100ulECM生物科学β-Actin小鼠单克隆IgG2b 9AM2021100ulECM生物科学α-肌动蛋白(C端区域)小鼠单克隆IgG111AP4241100ulECM生物科学β-Adaptin(N端区域)小鼠单克隆IgG113AX125550微克ECM生物科学肌动蛋白(N末端区域)封闭肽15AX167550微克<span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;">