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当前位置: 首页 > 产品中心 > Other_recombinant_protein > ECM BIOSCIENCES/EB3重组蛋白/100μl/EL7541
商品详细ECM BIOSCIENCES/EB3重组蛋白/100μl/EL7541
ECM BIOSCIENCES/EB3重组蛋白/100μl/EL7541
ECM BIOSCIENCES/EB3重组蛋白/100μl/EL7541
商品编号: EL7541
品牌: ecmbio
市场价: ¥1500.00
美元价: 750.00
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Microtubles (MTs) are oriented with a fast growing plus-end and a slower growing minus-end. The MT plus-end is a crucial site for the regulation of MT dynamics and MT association with different cellular organelles by several groups of plus-end tracking proteins (+TIPs). The End-Binding (EB) family of +TIPs includes EB1 (MAPRE1), EB2 (MAPRE2, RP1), and EB3 (MAPRE3, EBF3). EB proteins are ubiquitiously expressed +TIPs that can dimerize through a coiled-coil C-terminal region, and bind MTs through an N-terminal calponin homology domain. EB proteins can stabilize MTs, increase MT dynamics, and suppress MT pauses. Site specific phosphorylation may regulate EB activity. EB3 Ser-162 phosphorylation destabilizes EB3 dimer and reduces MT growth, while aurora-kinase induced Ser-176 phosphorylation regulates EB3 stability during mitosis.

Human recombinant EB3 is a full length protein with an N-terminal His-tag (34 kDa). The protein is detected by rabbit polyclonal anti-EB3 (a.a. 171-182) (Cat.#EP5121) and rat monoclonal EB3 (Cat.#EM5101).

References
Komarova, Y. et al. (2012) Mol Cell. 48:914. Gouveia, S.M. & Akhmanova, A. (2010) Int Rev Cell Mol Biol. 285:1.Komarova, Y. et al. (2005) Mol Biol Cell. 16(11):5334.
EB3 recombinant protein lysate is supplied at a concentration of 5 ng/µl in electrophoresis sample buffer (62.5 mM Tris pH 6.8, 2% SDS, 5% glycerol, 0.003% bromophenol blue, 0.9% β-mercaptoethanol). Store at –20°C. Do not boil or dilute. Stable for 1 year.

The products are are safely shipped at ambient temperature for both domestic and international shipments. Each product is guaranteed to match the specifications as indicated on the corresponding technical data sheet. Please store at -20C upon arrival for long term storage.

*All molecular weights (MW) are confirmed by comparison to Bio-Rad Rainbow Markers and to western blotmobilities of known proteins with similar MW.

This kit contains:

KIT SUMMARY

品牌介绍
ECM Biosciences是一家著名的生物公司,开发新的生物技术的生命科学研究。公司工程与研究机构全球发展创新的工具,以提高研究和治疗相关的神经病理学,癌症,免疫功能障碍和心血管疾病。产品列表:品牌名称1FM0141100微升ECM生物科学FXYD5 / Dysadherin(细胞外区域)小鼠单克隆IgG13AM2091100ulECM生物科学c-Abl(Tyr-245),磷酸化特异性兔多克隆5AP1271100ulECM生物科学Abp1(C端区域)小鼠单克隆IgG17AP1671100ulECM生物科学β-Actin小鼠单克隆IgG2b 9AM2021100ulECM生物科学α-肌动蛋白(C端区域)小鼠单克隆IgG111AP4241100ulECM生物科学β-Adaptin(N端区域)小鼠单克隆IgG113AX125550微克ECM生物科学肌动蛋白(N末端区域)封闭肽15AX167550微克<span line-height:2;"="" style="outline: none; font-size: 14px; font-family: "Microsoft YaHei"; line-height: 2;">